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Clomipramine, sold under the brand name Anafranil among others, is a tricyclic antidepressant (TCA). [7] It is used in the treatment of various conditions, most notably obsessive–compulsive disorder but also many other disorders, including hyperacusis, panic disorder, major depressive disorder, trichotillomania, [8] body dysmorphic disorder [9] [10] [11] and chronic pain. [7]
Clomipramine. Doxepin. Imipramine ... seizures (typically in combination with other drugs) and drug and alcohol withdrawal symptoms. ... and the medication is keeping your heart rate steady while ...
Anafranil (clomipramine) – a tricyclic antidepressant; mostly used to treat OCD; Antabuse – inhibits the enzyme acetaldehyde dehydrogenase, causing acetaldehyde poisoning when ethanol is consumed; used to cause severe hangover when drinking; increases liver, kidney, and brain damage from drinking
Chemical structure of the prototypical NaSSA mirtazapine (original brand name Remeron). Noradrenergic and specific serotonergic antidepressants (NaSSAs) are a class of psychiatric drugs used primarily as antidepressants. [1]
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Formation of norepinephrine is reduced by autoreceptors through the rate-limiting enzyme tyrosine hydroxylase, an effect mediated by decreased cyclic AMP-mediated phosphorylation-activation of the enzyme. [29] α 2 receptors also cause decreased intracellular cyclic AMP expression which results in smooth muscle relaxation or decreased secretion ...
Both loudness hyperacusis and noxacusis have been successfully treated with this drug. A dosage of up to 200–250 mg daily for a sustained period of six to twelve months may be needed to cure hyperacusis. A possible mechanism of action of this drug is that clomipramine reduces reactions of the autonomic nervous system to sounds. [53]
The sky-high seizure rate has been coupled with an 83% hike in criminal summonses issued to hell-on-wheels hacks so far this year, up to 3,467 from 1,892 during the same period last year.
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