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Bupivacaine, marketed under the brand name Marcaine among others, is a medication used to decrease sensation in a specific small area. [5] In nerve blocks , it is injected around a nerve that supplies the area, or into the spinal canal's epidural space . [ 5 ]
An autopsy report concluded that Kaspar died of an accident involving bupivacaine toxicity and the nerve-blocking agent was found in her bloodstream. Today's top stories: → Doctor found guilty ...
Levobupivacaine has become a more favourable alternative for regional anaesthesia than bupivacaine due to its reduced toxicity. A plethora of non-human studies have established levobupivacaine’s lower risk of cardiac and neurotoxic adverse effects.
The search for a less toxic and less addictive substitute led to the development of the aminoester local anesthetics stovaine in 1903 and procaine in 1904. Since then, several synthetic local anesthetic drugs have been developed and put into clinical use, notably lidocaine in 1943, bupivacaine in 1957, and prilocaine in 1959.
Lipid emulsions are effective in treating experimental models of severe cardiotoxicity from intravenous overdose of local anaesthetic drugs such as bupivacaine. [1] [2] [3] [4]
Misinformation runs rampant online about human papillomavirus and the HPV vaccine. Here's what to know about the vaccine credited with historic drops in cancer, including cervical cancer.
As for bupivacaine, Celepid, a commonly available intravenous lipid emulsion, can be effective in treating severe cardiotoxicity secondary to local anaesthetic overdose in animal experiments [5] and in humans in a process called lipid rescue. [6] [7] [8]
From 2018 to 2021, when overdose deaths were spiking across the country, the rate was 2.5 times as high in Carter County, according to the research organization NORC.