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Neramexane is a drug related to memantine, [1] which acts as an NMDA antagonist [2] and has neuroprotective effects. [3] It is being developed for various possible applications, including treatment of tinnitus, [4] [5] Alzheimer's disease, [6] drug addiction [7] and as an analgesic. [8]
Potential side effects may include temporary exacerbation of tinnitus symptoms, headache, or ear discomfort. Patients considering Neuromonics treatment should consult with a qualified audiologist or other healthcare professional to determine whether the treatment is appropriate for their specific needs. [1] [2]
XEN1101 works by selectively opening the KCNQ2/3 (K v 7.2/K v 7.3) voltage-gated potassium channels via positive allosteric modulation.The opening of these voltage-gated potassium channels, which are critical regulators of neuronal excitability, leads to an increase in the flow of potassium ions out of neurons.
Treatment #2: Hearing Aids As we mentioned, the majority of people with tinnitus also have some degree of hearing loss. The mechanism behind tinnitus causes the brain to generate its own ear noise.
It is being investigated as a possible treatment for reperfusion injury and stroke, [2] [3] Ménière's disease, [4] [5] hearing loss and tinnitus, [6] [7] and bipolar disorder. [8] [9] Additionally, ebselen may be effective against Clostridioides difficile infections [10] and has been shown to have antifungal activity against Aspergillus ...
The adverse effects found in the Phase II trial mainly affected the central nervous system, and appeared to be dose-related. [8] The most common adverse effects were drowsiness, dizziness, tinnitus and vertigo, confusion, and slurred speech. [9] Less common side effects included tremor, memory loss, gait disturbances, and double vision. [10]
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