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There is an association between rheumatoid factor and more persistently active synovitis, more joint damage, greater eventual disability and arthritis. [12] [13] Other than in rheumatoid arthritis, rheumatoid factor may also be elevated in other conditions, including: Systemic lupus erythematosus (SLE) [14] [15] Sjögren syndrome [14] [15]
Reference ranges (reference intervals) for blood tests are sets of values used by a health professional to interpret a set of medical test results from blood samples. Reference ranges for blood tests are studied within the field of clinical chemistry (also known as "clinical biochemistry", "chemical pathology" or "pure blood chemistry"), the ...
The typical rheumatoid nodule may be a few millimetres to a few centimetres in diameter and is usually found over bony prominences, such as the elbow, the heel, the knuckles, or other areas that sustain repeated mechanical stress. Nodules are associated with a positive RF (rheumatoid factor) titer, ACPA, and severe erosive arthritis. Rarely ...
[2] [3] Today, anti-histone antibodies are still used as a marker for systemic lupus erythematosus, but are also implicated in other autoimmune diseases like Sjögren syndrome, dermatomyositis, or rheumatoid arthritis. [4] [5] Anti-histone antibodies can be used as a marker for drug-induced lupus.
Laboratory tests (e.g. Erythrocyte Sedimentation Rate, Rheumatoid Factor, Anti-CCP (Anti-citrullinated protein antibody), ANA (Anti-Nuclear Antibody)) X-rays, Ultrasounds, and other imaging methods of affected joints; Cytopathology and chemical pathology of fluid aspirated from affected joints (e.g. to differentiate between septic arthritis and ...
Heterophile antibodies are of particular importance in clinical medicine for their use in detecting Epstein-Barr Virus (the causative agent of infectious mononucleosis). EBV infection induces the production of several antibody classes, of which heterophile antibodies are one (others include anti-i, rheumatoid factor and ANA). Heterophile ...
Immunofluorescence pattern of SS-A and SS-B antibodies. Produced using serum from a patient on HEp-20-10 cells with a FITC conjugate. Anti-SSA autoantibodies (anti–Sjögren's-syndrome-related antigen A autoantibodies, also called anti-Ro, or similar names including anti-SSA/Ro, anti-Ro/SSA, anti–SS-A/Ro, and anti-Ro/SS-A) are a type of anti-nuclear autoantibodies that are associated with ...
The diagnosis of RA was formerly based on detection of rheumatoid factor (RF). However, RF is also associated with other autoimmune diseases. The detection of anti-CCP is currently considered the most specific marker of RA. The diagnosis of rheumatoid lung disease is based on evaluation of pulmonary function, radiology, serology and lung biopsy.