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Tolvaptan, sold under the brand name Samsca among others, is an aquaretic drug that functions as a selective, competitive vasopressin receptor 2 (V 2) antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).
Tolvaptan, an aquaretic drug, is a vasopressin receptor 2 (V2) antagonist. [9] Pre-clinical studies had suggested that the molecule cAMP could be involved in the enlargement of ADPKD cysts, [ 42 ] and studies on rodents confirmed the role of vasopressin in increasing the levels of cAMP in the kidney, which laid the basis for the conduction of ...
Synthetic aquaretics are vasopressin receptor antagonists and include conivaptan, tolvaptan, demeclocycline, and mozavaptan (OPC-31260), as well as lithium. Conivaptan hydrochloride and tolvaptan have been approved by the FDA for treating syndrome of inappropriate antidiuretic hormone. [4] [5] Mozavaptan is approved in Japan. [citation needed]
The "vaptan" drugs act by directly blocking the action of vasopressin at its receptors (V 1A, V 1B and V 2).These receptors have a variety of functions, with the V 1A and V 2 receptors are expressed peripherally and involved in the modulation of blood pressure and kidney function respectively, while the V 1A and V 1B receptors are expressed in the central nervous system.
Tolvaptan phosphate is a drug used for the treatment of cardiac edema. It is a prodrug of tolvaptan , [ 1 ] [ 2 ] formulated as the salt tolvaptan sodium phosphate, for intravenous administration .
554 12000 Ensembl ENSG00000126895 ENSMUSG00000031390 UniProt P30518 O88721 RefSeq (mRNA) NM_000054 NM_001146151 NM_001276298 NM_001276299 NM_019404 RefSeq (protein) NP_000045 NP_001139623 NP_001263227 NP_001263228 NP_062277 Location (UCSC) Chr X: 153.9 – 153.91 Mb Chr X: 72.94 – 72.94 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Vasopressin receptor 2 (V2R), or arginine ...
From or to a drug trade name: This is a redirect from (or to) the trade name of a drug to (or from) the international nonproprietary name (INN).
Conivaptan, sold under the brand name Vaprisol, is a non-peptide inhibitor of the receptor for anti-diuretic hormone, also called vasopressin.It was approved in 2004 for hyponatremia (low blood sodium levels).