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The hook effect refers to the prozone phenomenon, also known as antibody excess, or the postzone phenomenon, also known as antigen excess. It is an immunologic phenomenon whereby the effectiveness of antibodies to form immune complexes can be impaired when concentrations of an antibody or an antigen are very high.
The effects of a stressor or drug generally depend on the exposure time. Therefore, the EC 50 (and similar statistics) will be a function of exposure time. The exact shape of this time function will depend upon the stressor (e.g., the specific toxicant), its mechanism of action, the organism exposed, etc.
ELISA plate showing various cortisol levels Enzymes used in ELISAs include horseradish peroxidase (HRP), alkaline phosphatase (AP) or glucose oxidase . These enzymes allow for detection often because they produce an observable color change in the presence of certain reagents.
Maintaining cardiorespiratory fitness could help lower the risk of dementia even in those who have higher genetic risk for it. Image credit: Justin Paget/Getty Images.
Elisa poses as a man so she can be with her one true love Marcela, and the lengths they go to are impressively romantic. Their first hook up will leave you speechless, tbh. Watch Now
A hook effect is commonly observed with high concentrations of PROTACs due to the bifunctional nature of the degrader. [15] Currently, pVHL and CRBN have been used in preclinical trials as E3 ligases. [15] However, there still remains hundreds of E3 ligases to be explored, with some giving the opportunity for cell specificity.
Here are some Mandela effect examples that have confused me over the years — and many others too. Grab your friends and see which false memories you may share. 1.
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