Search results
Results from the WOW.Com Content Network
The hook effect refers to the prozone phenomenon, also known as antibody excess, or the postzone phenomenon, also known as antigen excess. It is an immunologic phenomenon whereby the effectiveness of antibodies to form immune complexes can be impaired when concentrations of an antibody or an antigen are very high.
A hook effect is commonly observed with high concentrations of PROTACs due to the bifunctional nature of the degrader. [15] Currently, pVHL and CRBN have been used in preclinical trials as E3 ligases. [15] However, there still remains hundreds of E3 ligases to be explored, with some giving the opportunity for cell specificity.
Main page; Contents; Current events; Random article; About Wikipedia; Contact us
Discover the latest breaking news in the U.S. and around the world — politics, weather, entertainment, lifestyle, finance, sports and much more.
The effect can be demonstrated using a rubber band with weights attached to it. If the top of a rubber band is hung on a hook and small weights are attached to the bottom of the band one at a time, it will stretch and get longer.
If you believe in fairies, there’s a good chance you grew up loving the 1991 film Hook. The Steven Spielberg-directed adventure movie starred the late Robin Williams as Peter Banning, a.k.a. the ...
In physics, Hooke's law is an empirical law which states that the force (F) needed to extend or compress a spring by some distance (x) scales linearly with respect to that distance—that is, F s = kx, where k is a constant factor characteristic of the spring (i.e., its stiffness), and x is small compared to the total possible deformation of the spring.
Nonetheless, when Trump is inaugurated on January 20, he will be on the hook to make good on his promises. Here are seven ways a Trump administration could affect your personal finances. Child care