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Functional annotation of genes requires a controlled vocabulary (or ontology) to name the predicted functional features. However, because there are numerous ways to define gene functions, the annotation process may be hindered when it is performed by different research groups.
The Gene Ontology (GO) is a major bioinformatics initiative to unify the representation of gene and gene product attributes across all species. [1] More specifically, the project aims to: 1) maintain and develop its controlled vocabulary of gene and gene product attributes; 2) annotate genes and gene products, and assimilate and disseminate annotation data; and 3) provide tools for easy access ...
Since the 1980s, molecular biology and bioinformatics have created the need for DNA annotation. DNA annotation or genome annotation is the process of identifying attaching biological information to sequences, and particularly in identifying the locations of genes and determining what those genes do.
DNA annotation or genome annotation is the process of identifying the locations of genes and all of the coding regions in a genome and determining what those genes do. An annotation (irrespective of the context) is a note added by way of explanation or commentary. Once a genome is sequenced, it needs to be annotated to make sense of it. [49]
Knowledge base annotation is done based on the information of gene attribute, protein function and its metabolism. In this type of annotation more emphasis is given to genetic variation that disrupts the protein function domain, protein-protein interaction and biological pathway.
Gene-based annotation to identify exonic/splicing variants of the combination of SNVs and indels (~4.7 million variants) where a total of 24,617 exonic variants are identified. [1] Since Miller syndrome is a rare Mendelian disease, exonic protein-changing variants are of interest only, which makes up 11,166. [1]
The Gene Ontology (GO) provides a system for hierarchically classifying genes or gene products into terms organized in a graph structure (or an ontology).The terms are groups into three categories: molecular function (describing the molecular activity of a gene), biological process (describing the larger cellular or physiological role carried out by the gene, coordinated with other genes), and ...
Gene nomenclature is the scientific ... this action leaves the readers without any explanatory annotation and can leave them wondering what the apparent-abbreviation ...