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Korsakoff syndrome (KS) [1] is a disorder of the central nervous system characterized by amnesia, deficits in explicit memory, and confabulation.This neurological disorder is caused by a deficiency of thiamine (vitamin B 1) in the brain, and it is typically associated with and exacerbated by the prolonged, excessive ingestion of alcohol. [2]
In some regions, physicians have observed thiamine deficiency brought about by severe malnutrition, particularly in diets consisting mainly of polished rice, which is thiamine-deficient. The resulting nervous system ailment is called beriberi. In individuals with sub-clinical thiamine deficiency, a large dose of glucose (either as sweet food or ...
Thiamine deficiency is a medical condition of low levels of thiamine (vitamin B 1). [1] A severe and chronic form is known as beriberi. [1] [7] The name beriberi was possibly borrowed in the 18th century from the Sinhalese phrase බැරි බැරි (bæri bæri, “I cannot, I cannot”), owing to the weakness caused by the condition.
Alcoholic cardiomyopathy (ACM) is a disease in which the long-term consumption of alcohol leads to heart failure. [1] ACM is a type of dilated cardiomyopathy. The heart is unable to pump blood efficiently, leading to heart failure. It can affect other parts of the body if the heart failure is severe.
Vitamin B1 deficiency (thiamine deficiency) was reported to cause seizures, especially in alcoholics. [5] [6] [7] Vitamin B6 depletion (pyridoxine deficiency) was reported to be associated with pyridoxine-dependent seizures. [8] Vitamin B12 deficiency was reported to be the cause of seizures for adults [9] [10] and for infants. [11] [12]
Calcium and magnesium have been shown to affect the distribution of thiamine in the body and magnesium deficiency has been shown to aggravate thiamine deficiency. [22] Thiamine contents in human tissues are less than those of other species. [16] [64] The half-life of thiamine content stored in human body is about 9-18 days. [62]
“The event or death may have been related to the underlying disease being treated, may have been caused by some other product being used at the same time, or may have occurred for other reasons.” The Times story also cited a buprenorphine study by researchers in Sweden that looked at “100 autopsies where buprenorphine had been detected.”
The predominant cause of nutritional optic neuropathy is thought to be deficiency of B-complex vitamins, particularly thiamine [2] (vitamin B 1), cyanocobalamin (vitamin B 12) and recently copper. [3] Deficiency of pyridoxine (vitamin B 6), niacin (vitamin B 3), riboflavin (vitamin B 2), and/or folic acid also seems to play a role. Those ...