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The metabolism of metoprolol can vary widely among patients, often as a result of hepatic impairment [9] or CYP2D6 polymorphism. [10] Metoprolol was first made in 1969, patented in 1970, and approved for medical use in 1978. [11] [12] [13] It is on the World Health Organization's List of Essential Medicines. [14] It is available as a generic ...
The β-blockers are an immensely important class of drugs due to their high prevalence of use. The discovery of β-blockers reaches back to more than 100 years ago, when early investigators came up with the idea that catecholamines were binding selectively to receptor-like structures and that this was the cause of their pharmacological actions. [3]
In clinical trials and other scientific studies, an interim analysis is an analysis of data that is conducted before data collection has been completed. Clinical trials are unusual in that enrollment of subjects is a continual process staggered in time.
The first large study to show a mortality benefit from antihypertensive treatment was the VA-NHLBI study, which found that chlorthalidone was effective. [50] The largest study, Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) in 2002, concluded that chlorthalidone (a thiazide-like diuretic) was as effective ...
Noisy text analytics is a process of information extraction whose goal is to automatically extract structured or semistructured information from noisy unstructured text data. While Text analytics is a growing and mature field that has great value because of the huge amounts of data being produced, processing of noisy text is gaining in ...
A Miami Herald investigation into the boat crash that killed a 17-year-old Lourdes student reveals a deeply flawed probe as FWC investigators and prosecutors built a case against George Pino.
Nick Dunlap, a 20-year-old sophomore who plays golf for the University of Alabama, won the American Express tournament Sunday at the PGA West golf course in La Quinta, California.
Interact with 50-S subunit of the bacterial ribosome → stop bacterial protein synthesis; Tetracycline [45] [46] [47] [49] Interact with ribosomal 30-S subunit of bacteria → prevent bacterial protein synthesis; An image showing mechanism of action of antibiotics: Side effects [44] [47] For all antibiotics