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The lack of nutrients in the diet, or the lack of a balanced diet, can contribute to the discoloration of the area under the eyes. It is believed that iron deficiency and vitamin B 12 deficiency can cause dark circles as well. [7] Iron deficiency is the most common type of anemia and this condition is a sign that not enough oxygen is getting to ...
Without treatment, some of these problems may become permanent. [5] Pernicious anemia refers to a type of vitamin B 12 deficiency anemia that results from lack of intrinsic factor. [5] Lack of intrinsic factor is most commonly due to an autoimmune attack on the cells that create it in the stomach. [9]
A blue coloration of the sclera may be noticed in some cases of iron-deficiency anemia. [30] Vitamin B 12 deficiency anemia may result in decreased ability to think, memory loss, confusion, personality or mood changes, depression, difficulty walking, blurred vision, and irreversible nerve damage.
Furthermore, mongolian spots, large birthmarks, and the consumption of food products with blue or purple dyes can also result in the bluish skin tissue discoloration and may be mistaken for cyanosis. [ 2 ] [ 3 ] Appropriate physical examination and history taking is a crucial part to diagnose cyanosis.
Genetically induced chronic low-level methemoglobinemia may be treated with oral methylene blue daily. Also, vitamin C can occasionally reduce cyanosis associated with chronic methemoglobinemia, and may be helpful in settings in which methylene blue is unavailable or contraindicated (e.g., in an individual with G6PD deficiency). [22]
Emaciation manifests physically as thin limbs, pronounced and protruding bones, sunken eyes, dry skin, thinning hair, a bloated stomach, and a dry or coated tongue in humans. Emaciation is often accompanied by halitosis , hyponatremia , hypokalemia , anemia , improper function of lymph and the lymphatic system , and pleurisy and edema .
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Common, most foods do not contain vitamin D, indicating that a deficiency will occur unless people get sunlight exposure or eat manufactured foods purposely fortified with vitamin D. Vitamin D deficiency is a known cause of rickets, and has been linked to numerous other health problems. [46] [47] Vitamin E deficiency
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