Search results
Results from the WOW.Com Content Network
Setting aside other factors (e.g., balancing selection, and genetic drift), the equilibrium number of deleterious alleles is then determined by a balance between the deleterious mutation rate and the rate at which selection purges those mutations. Mutation–selection balance was originally proposed to explain how genetic variation is ...
In genetics, the K a /K s ratio, also known as ω or d N /d S ratio, [a] is used to estimate the balance between neutral mutations, purifying selection and beneficial mutations acting on a set of homologous protein-coding genes.
Selection coefficient, usually denoted by the letter s, is a measure used in population genetics to quantify the relative fitness of a genotype compared to other genotypes. . Selection coefficients are central to the quantitative description of evolution, since fitness differences determine the change in genotype frequencies attributable to selecti
Recently reported estimates of the human genome-wide mutation rate. The human germline mutation rate is approximately 0.5×10 −9 per basepair per year. [1]In genetics, the mutation rate is the frequency of new mutations in a single gene, nucleotide sequence, or organism over time. [2]
Balancing selection refers to a number of selective processes by which multiple alleles (different versions of a gene) are actively maintained in the gene pool of a population at frequencies larger than expected from genetic drift alone. Balancing selection is rare compared to purifying selection. [1]
Mutation will have a very subtle effect on allele frequencies through the introduction of new allele into a population. Mutation rates are of the order 10 −4 to 10 −8, and the change in allele frequency will be, at most, the same order. Recurrent mutation will maintain alleles in the population, even if there is strong selection against them.
The adaptive value can be measured by contribution of an individual to the gene pool of their offspring. The adaptive values are approximately calculated from the rates of change in frequency and mutation–selection balance. [2]
Mate selection to produce offspring is random, i.e. independent of fitness. First, new mutation step sizes are generated per mating by intermediate recombination of the parental σ j {\displaystyle {\sigma }_{j}} with subsequent mutation as follows: