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Pyridoxine, vitamin B6, is a water-soluble vitamin and is generally recognized as having no adverse effects. [9] [10] After diet changes, it alone is recommended as the secondary treatment plan. The most commonly reported adverse reaction of doxylamine is drowsiness. [11]
Pyridoxine (PN) [4] is a form of vitamin B 6 found commonly in food and used as a dietary supplement.As a supplement it is used to treat and prevent pyridoxine deficiency, sideroblastic anaemia, pyridoxine-dependent epilepsy, certain metabolic disorders, side effects or complications of isoniazid use, and certain types of mushroom poisoning. [5]
Vitamin B 6 Drug class Pyridoxal 5'-phosphate, the metabolically active form of vitamin B 6 Class identifiers Use Vitamin B 6 deficiency ATC code A11H Biological target enzyme cofactor Clinical data Drugs.com International Drug Names External links MeSH D025101 Legal status In Wikidata Vitamin B 6 is one of the B vitamins, and is an essential nutrient for humans. The term essential nutrient ...
[18] [37] It has been shown, in vivo, that supplementing with pyridoxal or pyridoxal phosphate increases pyridoxine concentrations in humans, meaning there are metabolic pathways from each vitamer of B 6 to the all other forms. [38] [39] Consuming high amounts of vitamin B 6 from food has not been reported to cause adverse effects. [24] [30] [40]
The medication is delivered chemically by the salt doxylamine succinate and is taken by mouth. Doxylamine and other first-generation antihistamines are the most widely used sleep medications in the world. [6] Typical side effects of doxylamine (at recommended doses) include dizziness, drowsiness, grogginess, and dry mouth, among others. [7] [4]
Adverse effects include nausea, headache, [2] and rarely allergic reaction (mild skin reactions). [3] A 2004 survey of six case reports suggested a link between pyritinol and severe cholestatic hepatitis when on several drugs for certain diseases. [4] Other rare side effects: acute pancreatitis [5] and photoallergic eruption. [6]
Metadoxine, also known as pyridoxine-pyrrolidone carboxylate, is a drug used to treat chronic and acute alcohol intoxication. [1] Metadoxine accelerates alcohol clearance from the blood. [2] Metadoxine is an ion pair salt of pyridoxine and pyrrolidone carboxylate (PCA). [1]
All patients and healthcare workers should be aware of these serious side effects, especially if suicidal ideation or behavior are suspected. [32] [33] [34] Isoniazid is associated with pyridoxine (vitamin B6) deficiency because of its similar structure. Isoniazid is also associated with increased excretion of pyridoxine.