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Probiotics, living bacteria with health benefits, are emerging as a potential tool to influence the microbiota-gut-brain axis and improve mental well-being. [29] This axis is a complex communication network linking the gut and the brain, primarily mediated by the vagus nerve and the production of neuromodulators, which influence nerve activity ...
The gut metagenome is the aggregate of all the genomes of gut microbiota. [24] The gut is one niche that human microbiota inhabit. [25] In humans, the gut microbiota has the largest quantity of bacteria and the greatest number of species, compared to other areas of the body. [26]
By positively modulating the gut microbiota, psychobiotics can impact the production of neurotransmitters, reduce inflammation, and enhance neural signaling, which may improve mental health and alleviate symptoms of neurological disorders. This highlights their potential as a therapeutic tool for maintaining a healthy gut-brain connection.
The brain-gut axis is a bidirectional mechanism in which psychosocial factors influence the GI tract and vice versa. Specifically, the emotional and cognitive centers of the brain influence GI activity and immune cell function, and the microbes within the gut regulate mood, cognition, and mental health. [29]
Challenges and priorities for researching the gut microbiota in individuals living with anorexia nervosa, 2023. [10] Nutrition and bipolar disorder: a systematic review, 2022. [11] Assessing the feasibility of an m-Health intervention for changing diet quality and mood in individuals with depression: the My Food & Mood program, 2021. [12]
Additionally, we established the role of gut microbiota and its metabolites as central to endometriosis pathogenesis, offering new avenues for combating the disease.” – Ramakrishna Kommagani, PhD
The establishment of a gut flora is crucial to the health of an adult, as well as the functioning of the gastrointestinal tract. [59] In humans, a gut flora similar to an adult's is formed within one to two years of birth as microbiota are acquired through parent-to-child transmission and transfer from food, water, and other environmental sources.
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