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Like many other medical conditions, obesity is the result of an interplay between environmental and genetic factors. [2] [3] Studies have identified variants in several genes that may contribute to weight gain and body fat distribution; although, only in a few cases are genes the primary cause of obesity. [4] [5]
Scientists from the University of Exeter Medical School have found that people missing a specific blood group due to a genetic variant may be genetically predisposed to having obesity or overweight.
Monogenic obesity is excess weight caused by a mutation in a single gene, as opposed to syndromic obesity not tied to a single gene variation and most obesity, which is caused by multiple genetic and environmental risk factors. Monogenetic obesity mostly affects the hypothalamus and leptin–melanocortin system (see hypothalamic obesity ...
These associations were not attenuated when fat intake and calorie intake was accounted for. [37] [38] Similarly, heavy consumption of fried food is linked to greater obesity risk on a population level. [39] On a more individual level, the relative risk of fried food consumption and increased weight gain seems to depend on genetic ...
Numerous studies aimed to provide insight into genetic, economic, and/or environmental causes of obesity. According to the "thrifty gene hypothesis, [18] a genetic theory explaining rising obesity rates, certain individuals are genetically predisposed to metabolize food more efficiently than others as a result of human evolution. In times of ...
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However, genes that promote only limited fat deposition in the context of pre-industrialized lifestyles and diets may promote excessive fat deposition and obesity when caloric intake is increased and expenditure is decreased beyond the range of the environments these genes evolved in (a gene x environment interaction).
With volume eating, people focus on having high-volume foods, which tend to have a lot of fiber and water, giving you less calories per gram, says Jessica Cording, R.D., author of The Little Book ...