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CD68 immunostaining demonstrating macrophages and giant cells in a case of xanthogranulomatous pyelonephritis CD68 ( C luster of D ifferentiation 68) is a protein highly expressed by cells in the monocyte lineage (e.g., monocytic phagocytes , osteoclasts ), by circulating macrophages , and by tissue macrophages (e.g., Kupffer cells , microglia ).
The mononuclear phagocytic system is part of the organism's immune system. The histiocyte is a tissue macrophage [1] or a dendritic cell [2] (histio, diminutive of histo, meaning tissue, and cyte, meaning cell). Part of their job is to clear out neutrophils once they've reached the end of their lifespan.
Immunohistochemistry demonstrates that vascular endothelial cells are positive for Factor VIII, vimentin, CD31, and CD34 antibodies, [11] [12] but negative for Bcl-2 and HHV-8 antigens. [13] [14] Vimentin, Factor XIIIa, CD68, alpha-1-antitrypsin, and lysozyme are expressed by mononuclear cells, [11] [13] although neither S100 nor CD1a are. [12]
Giant cells are also known to develop when infections are present. They were first observed as early as the middle of the last century, but it is not fully understood why these reactions occur. In the process of giant cell formation, monocytes or macrophages fuse together, which could cause multiple problems for the immune system. [citation needed]
Angiology (from Greek ἀγγεῖον, angeīon, "vessel"; and -λογία, -logia) is the medical specialty dedicated to studying the circulatory system and of the lymphatic system, i.e., arteries, veins and lymphatic vessels. [1] In the UK, this field is more often termed angiology, and in the United States the term vascular medicine is
Mast cell activation syndrome (MCAS) is a term referring to one of two types of mast cell activation disorder (MCAD); the other type is idiopathic MCAD. [1] MCAS is an immunological condition in which mast cells, a type of white blood cell, inappropriately and excessively release chemical mediators, such as histamine, resulting in a range of chronic symptoms, sometimes including anaphylaxis or ...
Necrotizing vasculitis, also called systemic necrotizing vasculitis, [1] is a general term for the inflammation of veins and arteries that develops into necrosis and narrows the vessels. [ 2 ] Tumors , medications, allergic reactions , and infectious organisms are some of the recognized triggers for these conditions, even though the precise ...
Anatomical terms of microanatomy [ edit on Wikidata ] A megakaryocyte (from mega- 'large' karyo- ' cell nucleus ' and -cyte ' cell ') is a large bone marrow cell with a lobated nucleus that produces blood platelets (thrombocytes), which are necessary for normal clotting .