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The cobwebs produced by spiders in the genus Atypus, called Huidouba, have traditionally been consumed in Sichuan and Tibet to manage the symptoms of diabetes. Several studies have corroborated their therapeutic effects. [6] Peasants in the southern Carpathian Mountains used to cut up tubes built by Atypus and cover wounds with the inner lining ...
At higher doses (100 μg/spider), the shape changed more, and the web design became irregular. All the drugs tested reduced web regularity except for small doses (0.1–0.3 μg) of LSD, which increased web regularity. [12] The drugs were administered by dissolving them in sugar water, and a drop of solution was touched to the spider's mouth. In ...
Thiazolidinedione ligand dependent transactivation is responsible for the majority of anti-diabetic effects. The activated PPAR/RXR heterodimer binds to peroxisome proliferator hormone response elements upstream of target genes in complex with a number of coactivators such as nuclear receptor coactivator 1 and CREB binding protein, this causes upregulation of genes (for a full list see PPARγ):
A classic circular form spider's web Infographic illustrating the process of constructing an orb web. A spider web, spiderweb, spider's web, or cobweb (from the archaic word coppe, meaning 'spider') [1] is a structure created by a spider out of proteinaceous spider silk extruded from its spinnerets, generally meant to catch its prey.
Drugs used in diabetes treat diabetes mellitus by decreasing glucose levels in the blood. With the exception of insulin , most GLP-1 receptor agonists ( liraglutide , exenatide , and others), and pramlintide , all diabetes medications are administered orally and are thus called oral hypoglycemic agents or oral antihyperglycemic agents.
“Just as much as the GLP-1s are a diabetes drug and a weight loss medicine, they are brain drugs, too,” says Rekha Kumar, MD, an endocrinologist at New York-Presbyterian and Weill Cornell ...
Diabetes is the leading known cause of neuropathy in developed countries, and neuropathy is the most common complication and greatest source of morbidity and mortality in diabetes. A systematic review has found that diabetic peripheral neuropathy affects 30% of diabetes patients. [ 1 ]
Most neurons have the ability to use other fuels besides glucose (e.g. lactic acid, ketones).Knowledge of the "switchover" process is incomplete. [further explanation needed] The most severe neuroglycopenic symptoms occur with hypoglycemia caused by excess insulin because insulin reduces the availability of other fuels by suppressing ketogenesis and gluconeogenesis.