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STR analysis is a tool in forensic analysis that evaluates specific STR regions found on nuclear DNA.The variable (polymorphic) nature of the STR regions that are analyzed for forensic testing intensifies the discrimination between one DNA profile and another. [3]
Rapid DNA (UK:Rapid DNA profiling) describes the fully automated (hands free) process of developing a CODIS Core STR profile or other STR profile from a reference sample buccal swab. The “swab in – profile out” process consists of automated extraction, amplification , separation, detection and allele calling without human intervention. [ 1 ]
STR analysis has become the gold standard for DNA profiling and is used extensively in forensic applications. STR analysis can also be restricted to just the Y chromosome . Y-STR analysis can be used in cases that involve paternity or in familial searching as the Y chromosome is identical down the paternal line (except in cases where a mutation ...
A microsatellite is a tract of tandemly repeated (i.e. adjacent) DNA motifs that range in length from one to six or up to ten nucleotides (the exact definition and delineation to the longer minisatellites varies from author to author), [1] [6] and are typically repeated 5–50 times.
The DNA lysate is further purified and used to generate an autosomal STR profile of the victim. To further obtain the male DNA which will identify the perpetrator, harsher lysis conditions will be applied afterwards to the very same filter column without the necessity of sample carriage in order to break open the retained spermatozoa.
STR polymorphisms are genetic markers that may be used to identify a DNA sequence. The FBI analyses 13 specific STR loci for their database. These may be used in many areas of genetics in addition to their forensic uses. One can think of a STR multiplex system as a collection of specific STRs which are positionally conserved on a target genome.
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