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Two non-exclusive mechanisms have been postulated. Firstly, in the context of aging and neurodegeneration, the integrity of the blood-brain barrier (BBB) can become compromised, resulting in increased permeability. Notably, amyloid plaques have been hypothesized to counteract this BBB leakage. [7]
Amyloid plaques (also known as neuritic plaques, amyloid beta plaques or senile plaques) are extracellular deposits of amyloid beta (Aβ) ...
The advantage of 18F-FDG PET for these uses is its much wider availability. Some radioactive tracers used for Alzheimer's are florbetapir 18F, flutemetamol F18, PiB and florbetaben 18F, which are all used to detect amyloid-beta plaques (a potential biomarker for Alzheimer's) in the brain.
In Alzheimer's disease, MRI scans of the entire brain can accurately assess the rate of hippocampal atrophy, [38] [39] while PET scans can measure the brain's metabolic activity by measuring regional glucose metabolism, [33] and beta-amyloid plaques using tracers such as Pittsburgh compound B (PiB).
Amyloid-Related Imaging Abnormalities – Edema (ARIA-E) where there is the development of brain swelling or edema, which can lead to symptoms like headache or confusion.
New research is contradicting previously held views that only neurons secret beta-amyloid that forms toxic plaques, a marker of Alzheimer's disease in the brain. The study points to another ...
Pittsburgh compound B (PiB) is a radioactive analog of thioflavin T, which can be used in positron emission tomography scans to image beta-amyloid plaques in neuronal tissue. Due to this property, Pittsburgh compound B may be used in investigational studies of Alzheimer's disease.
This can be supported by a blood test currently in development to identify patients with an active HCMV infection. “This subtype of Alzheimer’s includes the hallmark amyloid plaques and tau ...