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Although corticobasal degeneration has a plethora of symptoms, some are more prevalent than others. In a study of 147 patients with CBD, it was found that all of them had at least one Parkinsonian sign, 95% having two and 93% had some higher order dysfunction (cognitive impairments like acalculia, sensory loss, dementia, neglect, etc.).
Corticobasal syndrome (CBS) is a rare, progressive atypical Parkinsonism syndrome and is a tauopathy related to frontotemporal dementia. [ 1 ] [ 2 ] CBS is typically caused by the deposit of tau proteins forming in different areas of the brain.
Progressive supranuclear palsy (PSP) is a late-onset neurodegenerative disease involving the gradual deterioration and death of specific volumes of the brain. [1] [2] The condition leads to symptoms including loss of balance, slowing of movement, difficulty moving the eyes, and cognitive impairment. [1]
Neurodegenerative conditions and Parkinson-plus syndromes that can cause parkinsonism include: [6] Corticobasal degeneration [6] Dementia with Lewy bodies [6] The relationship (if any) with essential tremor is not clear. [7] Frontotemporal dementia (Pick's disease) [8] Gerstmann–Sträussler–Scheinker syndrome [6] Huntington's disease [6]
The symptoms of this dementia depend on where in the brain the strokes occurred and whether the blood vessels affected were large or small. [13] Repeated injury can cause progressive dementia over time, while a single injury located in an area critical for cognition such as the hippocampus, or thalamus, can lead to sudden cognitive decline. [69]
They include multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD). Dementia with Lewy bodies (DLB), may or may not be part of the PD spectrum, but it is increasingly recognized as the second-most common type of neurodegenerative dementia after Alzheimer's disease.
In some cases, dry macular degeneration can convert to “wet” degeneration, caused by “bleeding or a leaky blood vessel,” that leads to a much more rapid loss of visual acuity, explains ...
Treatment is supportive as with other forms of dementia. [39] Those with CTE-related symptoms may receive medication and non-medication-related treatments. [40] Currently, there is no way to stop or slow the development of chronic traumatic encephalopathy (CTE).
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