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Non-small cell lung cancer (NSCLC) cells expressing programmed death-ligand 1 (PD-L1) could interact with programmed death receptor 1 (PD-1) expressed on the surface of T cells, and result in decreased tumor cell kill by the immune system. Atezolizumab is an anti PD-L1 monoclonal antibody.
In normal epithelial tissues, epithelial cells, or parenchymal cells of epithelia, are highly organized, polar cells. [5] These cells are separated from stromal cells by a basement membrane that prevents these cell populations from mixing. [5] A mixture of these cell types is recognized, normally, as a wound, as in the example of a cut to the ...
LCC is categorized as a type of NSCLC (non-small-cell lung carcinoma) that originates from epithelial cells of the lung. LCLC is histologically characterized by the presence of large, undifferentiated cells that lack distinctive features of either squamous cell carcinoma or adenocarcinoma (other types of cancers).
Examples of epithelial dysplasia include cervical intraepithelial neoplasia – a disorder commonly detected by an abnormal pap smear) consisting of an increased population of immature (basal-like) cells which are restricted to the mucosal surface, and have not invaded through the basement membrane to the deeper soft tissues.
"Dyskaryosis" is a term used for all squamous mucosal surfaces and commonly used for the uterine cervix condition in which some of the epithelial cells near the external orifice show abnormalities in their cellular nuclei. These changes are often quite subtle; often seen as temporary changes between the ages of fifteen and twenty-five.
A squamous intraepithelial lesion (SIL) is an abnormal growth of epithelial cells on the surface of the cervix, commonly called squamous cells. This condition can lead to cervical cancer , but can be diagnosed using a Pap smear or a colposcopy .
The cells in the respiratory epithelium are of five main types: a) ciliated cells, b) goblet cells, c) brush cells, d) airway basal cells, and e) small granule cells (NDES) [6] Goblet cells become increasingly fewer further down the respiratory tree until they are absent in the terminal bronchioles; club cells take over their role to some extent here. [7]
For example, a lipoma is a common benign tumor of fat cells , and a chondroma is a benign tumor of cartilage-forming cells (chondrocytes). Adenomas are benign tumors of gland-forming cells, and are usually specified further by their cell or organ of origin, as in hepatic adenoma (a benign tumor of hepatocytes, or liver cells).