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  2. Vaccination - Wikipedia

    en.wikipedia.org/wiki/Vaccination

    Vaccination is the administration of a vaccine to help the immune system develop immunity from a disease. Vaccines contain a microorganism or virus in a weakened, live or killed state, or proteins or toxins from the organism. In stimulating the body's adaptive immunity, they help prevent sickness from an infectious disease.

  3. Vaccinia - Wikipedia

    en.wikipedia.org/wiki/Vaccinia

    The most common notion is that vaccinia virus, cowpox virus, and variola virus (the causative agent of smallpox) were all derived from a common ancestral virus. There is also speculation that vaccinia virus was originally isolated from horses , [ 9 ] and analysis of DNA from an early (1902) sample of smallpox vaccine showed that it was 99.7% ...

  4. Vaccine - Wikipedia

    en.wikipedia.org/wiki/Vaccine

    One challenge in vaccine development is economic: Many of the diseases most demanding a vaccine, including HIV, malaria and tuberculosis, exist principally in poor countries. Pharmaceutical firms and biotechnology companies have little incentive to develop vaccines for these diseases because there is little revenue potential. Even in more ...

  5. COVID-19 vaccine misinformation and hesitancy - Wikipedia

    en.wikipedia.org/wiki/COVID-19_vaccine...

    Prior to the vaccine launch many citizens expressed skepticism that COVID-19 was a serious disease or that their countries had cases or high number of cases of the disease during 2020 and 2021. This prior skepticism that was pushed by the late President of Tanzania , John Pombe Magufuli is seen as a leading reason for vaccine hesitancy within ...

  6. Breakthrough infection - Wikipedia

    en.wikipedia.org/wiki/Breakthrough_infection

    Causes of breakthrough infections include biological factors in the recipient, improper administration or storage of vaccines, mutations in viruses, blocking antibody formation, and other factors. For these reasons, vaccines are rarely 100% effective. A 2021 study found the common flu vaccine provided immunity to the flu in 58% of recipients. [6]

  7. mRNA vaccine - Wikipedia

    en.wikipedia.org/wiki/MRNA_vaccine

    An mRNA vaccine is a type of vaccine that uses a copy of a molecule called messenger RNA (mRNA) to produce an immune response. [1] The vaccine delivers molecules of antigen-encoding mRNA into cells, which use the designed mRNA as a blueprint to build foreign protein that would normally be produced by a pathogen (such as a virus) or by a cancer ...

  8. ChAdOx1 - Wikipedia

    en.wikipedia.org/wiki/ChAdOx1

    The COVID-19 vaccine, known now as ChAdOx1 nCoV-19 or AZD1222, makes use of this vector, which stimulates an immune response against the coronavirus spike protein. [ 12 ] [ 13 ] Animal studies began in March 2020, and recruitment of 510 human participants for a phase I/II trial began on 27 March, [ 17 ] [ 18 ] [ 19 ] and the results were ...

  9. Inactivated vaccine - Wikipedia

    en.wikipedia.org/wiki/Inactivated_vaccine

    An inactivated vaccine (or killed vaccine) is a type of vaccine that contains pathogens (such as virus or bacteria) that have been killed or rendered inactive, so they cannot replicate or cause disease. In contrast, live vaccines use pathogens that are still alive (but are almost always attenuated, that is, weakened).

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