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  2. Deletion (genetics) - Wikipedia

    en.wikipedia.org/wiki/Deletion_(genetics)

    Deletion on a chromosome. In genetics, a deletion (also called gene deletion, deficiency, or deletion mutation) (sign: Δ) is a mutation (a genetic aberration) in which a part of a chromosome or a sequence of DNA is left out during DNA replication.

  3. Structural variation - Wikipedia

    en.wikipedia.org/wiki/Structural_variation

    The divergence from this distribution is investigated to discover duplications and deletions. Regions with duplication will show higher read depth while those with deletion will result in lower read depth. Split-read methods enable detection of insertions (including mobile element insertions) and deletions down to single base-pair resolution ...

  4. Mobile genetic elements - Wikipedia

    en.wikipedia.org/wiki/Mobile_genetic_elements

    An example of MGEs in evolutionary context are that virulence factors and antibiotic resistance genes of MGEs can be transported to share genetic code with neighboring bacteria. However, MGEs can also decrease fitness by introducing disease-causing alleles or mutations. [ 3 ]

  5. Mutagenesis (molecular biology technique) - Wikipedia

    en.wikipedia.org/wiki/Mutagenesis_(molecular...

    Types of mutations that can be introduced by random, site-directed, combinatorial, or insertional mutagenesis. In molecular biology, mutagenesis is an important laboratory technique whereby DNA mutations are deliberately engineered to produce libraries of mutant genes, proteins, strains of bacteria, or other genetically modified organisms. The ...

  6. Unequal crossing over - Wikipedia

    en.wikipedia.org/wiki/Unequal_crossing_over

    Unequal crossing over is a type of gene duplication or deletion event that deletes a sequence in one strand and replaces it with a duplication from its sister chromatid in mitosis or from its homologous chromosome during meiosis. It is a type of chromosomal crossover between homologous sequences that are not paired precisely. Normally genes are ...

  7. Conservative replacement - Wikipedia

    en.wikipedia.org/wiki/Conservative_replacement

    A conservative replacement (also called a conservative mutation or a conservative substitution or a homologous replacement) is an amino acid replacement in a protein that changes a given amino acid to a different amino acid with similar biochemical properties (e.g. charge, hydrophobicity and size). [1] [2]

  8. Modifications (genetics) - Wikipedia

    en.wikipedia.org/wiki/Modifications_(genetics)

    There are several methods, or forms, of mutation that exist including spontaneous mutation, errors during replication and repair, as well as mutation due to environmental effects. [8] These origins of mutations can cause many different types of mutations which influence gene expression on both large and small scales.

  9. Deletion mapping - Wikipedia

    en.wikipedia.org/wiki/Deletion_mapping

    In genetics and especially genetic engineering, deletion mapping is a technique used to find out the mutation sites within a gene. The principle of deletion mapping involves crossing a strain which has a point mutation in a gene, with multiple strains who each carry a deletion in a different region of the same gene.

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