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In March 2017, ocrelizumab was approved in the United States for the treatment of primary progressive multiple sclerosis in adults. [22] [42] It is also used for the treatment of relapsing forms of multiple sclerosis, to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease in adults. [42]
It may be that primary MS fatigue is unaffected by sleep characteristics, but that sleep deprivation correlates with secondary MS fatigue. [155] CPAP treatment in patients with MS and sleep apnea may reduce fatigue and improve the physical quality of life. [156]
Management of ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome) focuses on symptoms management, as no treatments that address the root cause of the illness are available. [1]: 29 Pacing, or regulating one's activities to avoid triggering worse symptoms, is the most common management strategy for post-exertional malaise.
Multiple sclerosis (MS) is an autoimmune disorder in which the immune system attacks and destroys the myelin sheath of nerve cells. It most commonly strikes people between the ages of 20 and 40.
[96] [97] [98] MS fatigue can be affected by body heat, [78] [80] and this may differentiate MS fatigue from other primary fatigue. [ 40 ] [ 41 ] [ 84 ] Fatigability (loss of strength) may increase perception of fatigue, but the two measures warrant independent assessment in clinical studies.
The Canadian Consensus Criteria require "post exertional malaise and/or [post exertional] fatigue" instead. [20] [21] [22] [18] [23] On the other hand, the older Oxford Criteria lack any mention of PEM, [24] and the Fukuda Criteria consider it optional. Depending on the definition of ME/CFS used, PEM is present in 60 to 100% of ME/CFS patients. [6]
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