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Tolvaptan, sold under the brand name Samsca among others, is an aquaretic drug that functions as a selective, competitive vasopressin receptor 2 (V 2) antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).
It is a prodrug of tolvaptan, [1] [2] formulated as the salt tolvaptan sodium phosphate, for intravenous administration. Tolvaptan phosphate is converted into the active drug tolvaptan in the human body following administration. It was developed by Otsuka Pharmaceutical Co. and was approved for use in Japan in 2022. [3]
The "vaptan" drugs act by directly blocking the action of vasopressin at its receptors (V 1A, V 1B and V 2).These receptors have a variety of functions, with the V 1A and V 2 receptors are expressed peripherally and involved in the modulation of blood pressure and kidney function respectively, while the V 1A and V 1B receptors are expressed in the central nervous system.
A woman accused of sneaking onto a Delta Air Lines flight from New York to Paris was arraigned last week and charged with knowingly stowing away aboard an aircraft without consent. Svetlana Dali ...
Andy Cohen is spilling the tea on what it's like working with longtime friend and colleague Anderson Cooper. Before SiriusXM's 10th Annual Radio Andy Holiday Hangout (which he co-hosts with Amy ...
ATC code C03 Diuretics is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
When you need a comforting addition to your Christmas dinner spread, make Grandma proud with one of these flavorful main and side dish casseroles. This collection of warm and cozy casseroles ...
This is an accepted version of this page This is the latest accepted revision, reviewed on 1 January 2025. This is a dynamic list and may never be able to satisfy particular standards for completeness. You can help by adding missing items with reliable sources. Indian record label T-Series is the most-viewed YouTube channel, with over 276 billion views. The list of most-viewed YouTube channels ...