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Bromocriptine is a partial agonist of the dopamine D 2 receptor. [ 21 ] [ 22 ] [ 23 ] It also interacts with other dopamine receptors and with various serotonin and adrenergic receptors . [ 21 ] [ 22 ] [ 24 ] Bromocriptine has additionally been found to inhibit the release of glutamate by reversing the GLT1 glutamate transporter .
Whereas D 2 receptor agonists suppress prolactin secretion, dopamine D 2 receptor antagonists like domperidone and metoclopramide have the opposite effect, strongly inducing the pituitary secretion of prolactin, and are sometimes used as prolactin releasers, for instance to correct hypoprolactinemia (low prolactin levels) in the treatment of lactation failure. [2]
Management includes stopping the triggering medication, rapid cooling, and starting other medications. [2] Medications used include dantrolene, bromocriptine, and diazepam. [2] The risk of death among those affected is about 10%. [4] Rapid diagnosis and treatment is required to improve outcomes. [1]
NEW YORK (Reuters) -The man accused of killing a woman sleeping on a New York City subway car by setting her on fire after what prosecutors say was a night of heavy drinking pleaded not guilty to ...
Dopamine agonists are primarily used in the treatment of the motor symptoms of Parkinson's disease, and to a lesser extent, in hyperprolactinemia and restless legs syndrome. [2] [3] They are also used off-label in the treatment of clinical depression. Impulse control disorders are associated with the use of dopamine agonists for whatever ...
A man who had been arrested on suspicion of the murder of Kyran Durnin is believed to have died. Gardaí (Irish police) and emergency services found the body of 36-year-old, named locally as ...
Carlos Santana is on the mend after an accidental fall at his home in Hawaii left him with a broken finger.. The legendary guitarist, 77, was set to begin a new set of shows in his Las Vegas ...
[1] [53] [54] A systematic review and meta-analysis has shown that cabergoline and quinagolide are more effective in the treatment of hyperprolactinemia compared to bromocriptine, [55] this is because evidence had suggested fewer side effects, rapid titration and offers better dosing interval in medication like quinagolide compared to ...