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The name mineralocorticoid derives from early observations that these hormones were involved in the retention of sodium, a mineral.The primary endogenous mineralocorticoid is aldosterone, although a number of other endogenous hormones (including progesterone [1] and deoxycorticosterone) have mineralocorticoid function.
Aldosterone is the main mineralocorticoid steroid hormone produced by the zona glomerulosa of the adrenal cortex in the adrenal gland. [4] [5] It is essential for sodium conservation in the kidney, salivary glands, sweat glands, and colon. [6]
Mineralocorticoids (such as aldosterone) produced in the zona glomerulosa help in the regulation of blood pressure and electrolyte balance. The glucocorticoids cortisol and cortisone are synthesized in the zona fasciculata; their functions include the regulation of metabolism and immune system suppression.
110784 Ensembl ENSG00000151623 ENSMUSG00000031618 UniProt P08235 Q8VII8 RefSeq (mRNA) NM_000901 NM_001166104 NM_001354819 NM_001083906 RefSeq (protein) NP_000892 NP_001159576 NP_001341748 n/a Location (UCSC) Chr 4: 148.08 – 148.44 Mb Chr 8: 77.63 – 77.97 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The mineralocorticoid receptor (or MR, MLR, MCR), also known as the aldosterone ...
Adrenocortical hormones are divided into three classes by function: mineralocorticoids, glucocorticoids, and androgens. Mineralocorticoid hormones are synthesized in the outermost layer of the adrenal cortex known as the zona glomerulosa. [2] Their function is to regulate the concentration of electrolytes circulating in the blood. [1]
Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones.Two main classes of corticosteroids, glucocorticoids and mineralocorticoids, are involved in a wide range of physiological processes, including stress response, immune response, and regulation of inflammation, carbohydrate metabolism ...
It also serves as a secondary stimulus for the synthesis of mineralocorticoids such as aldosterone, which serve an important role in regulating the salt balance of the blood. [13] Glucocorticoids released by the adrenal cortex inhibit production of CRH and ACTH, forming a negative feedback loop.
One study in 1992 found ACE in all blood vessel endothelial cells. [ 10 ] Angiotensin II is the major bioactive product of the renin–angiotensin system, binding to receptors on intraglomerular mesangial cells , causing these cells to contract along with the blood vessels surrounding them; and to receptors on the zona glomerulosa cells ...