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Osteopontin also drives metastasis by triggering the release of vascular endothelial growth factor (VEGF) and matrix metalloprotease (MMP), which is inhibited by knocking down osteopontin. This process is also stimulated by nicotine, which is the proposed mechanism by which smokers experience elevated PC risk.
104099 Ensembl ENSG00000144668 ENSMUSG00000039115 UniProt Q13797 B8JK39 RefSeq (mRNA) NM_002207 NM_001113514 NM_133721 RefSeq (protein) NP_002198 NP_001106986 NP_598482 Location (UCSC) Chr 3: 37.45 – 37.82 Mb Chr 9: 118.44 – 118.73 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Integrin alpha-9 is a protein that in humans is encoded by the ITGA9 gene. Cytogenetic location: 3p22 ...
OPN may stand for: . Osteopontin, a glycoprotein secreted by osteoblasts; Object Process Network, a simulation model meta-language; Optics & Photonics News, a magazine; Oneohtrix Point Never, recording alias of musician Daniel Lopatin
Minor, but important, amounts of small proteins, including osteocalcin and osteopontin, are secreted in bone's organic matrix. [21] Osteocalcin is not expressed at significant concentrations except in bone, and thus osteocalcin is a specific marker for bone matrix synthesis. [ 22 ]
Osteopontin secretion may be able to regulate synaptogenesis and target the necessary neuroglia required for the repair of the axons. A study done by Julie L. Chan proves the functionality of osteopontin in initiating the immune response necessary for synaptic repair and reorganization after injury (axotomy). [ 11 ]
osteopontin (OPN) bone sialoprotein (BSP) dentin matrix protein 1 (DMP1) dentin sialophosphoprotein (DSPP) matrix extracellular phosphoglycoprotein (MEPE) The genes coding for members of the SIBLING protein family are similarly organized and are all located on human chromosome 4q21-23. [3]
Arginylglycylaspartic acid (RGD) is the most common peptide motif responsible for cell adhesion to the extracellular matrix (ECM), found in species ranging from Drosophila to humans.
Also in XLH, where PHEX enzymatic activity is absent or reduced, osteopontin [31] —a mineralization-inhibiting secreted substrate protein found in the extracellular matrix of bone [32] —accumulates in bone (and teeth) to contribute to the osteomalacia (and odontomalacia) as shown in the mouse homolog (Hyp) of XLH and in XLH patients. [33 ...