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Joel Fagliano (born 1992 [1]) is an American puzzle creator. [2] [3] [4] He is known for his work at The New York Times, where he writes the paper's Mini Crossword. [5]From March 14 to December 29, 2024, Fagliano became the interim editor of The New York Times Crossword due to editor Will Shortz being on medical leave.
Frank Longo is an American puzzle creator and author of more than 90 books, [1] which have sold more than 2 million copies. [2]Longo is known for creating unusual crosswords, such as one on a 50x50 grid, [3] [4] the Jumbo Puzzles compilation of 29x29 puzzles [5] and is the creator and author of The New York Times Spelling Bee anagram puzzle.
Alzheimer's disease (AD) is a neurodegenerative disease that usually starts slowly and progressively worsens. [2] It is the cause of 60–70% of cases of dementia. [2] [15] The most common early symptom is difficulty in remembering recent events. [1]
The number of people with the disease is expected to more than double in the next 40 years, from 6.1 million patients in 2020 to around 14 million in 2060, according to the Alzheimer's Association.
Crossword-like puzzles, for example Double Diamond Puzzles, appeared in the magazine St. Nicholas, published since 1873. [32] Another crossword puzzle appeared on September 14, 1890, in the Italian magazine Il Secolo Illustrato della Domenica. It was designed by Giuseppe Airoldi and titled "Per passare il tempo" ("To pass the time"). Airoldi's ...
Age-related neuropathologies such as Alzheimer's disease, Parkinson's disease, diabetes, hypertension and arteriosclerosis make it difficult to distinguish the normal patterns of aging. [ 18 ] [ 19 ] One of the important differences between normal aging and pathological aging is the location of neurofibrillary tangles.
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