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Estradiol levels on the first day after single dose of 0.25 mg buccal estradiol or at steady state after the last dose with 0.25 mg buccal estradiol twice daily once every 12 hours (0.5 mg/day total) in 6 postmenopausal women. [142] Estradiol has been studied for use by buccal administration.
Estradiol is an estrogen, or an agonist of the nuclear estrogen receptors (ERs), the estrogen receptor alpha (ERα) and the estrogen receptor beta (ERβ). [1] [2] [6] In one study, the EC 50 Tooltip half-maximal effective concentration value of estradiol for the human ERα was 50 pM (0.05 nM) and for the human ERβ was 200 pM (0.2 nM).
Estradiol is responsible for the development of female secondary sexual characteristics such as the breasts, widening of the hips and a female pattern of fat distribution. It is also important in the development and maintenance of female reproductive tissues such as the mammary glands, uterus and vagina during puberty, adulthood and pregnancy. [7]
Menopause, also known as the climacteric, is the time when menstrual periods permanently stop, marking the end of reproduction. [1] [6] [7] It typically occurs between the ages of 45 and 55, although the exact timing can vary. [8] Menopause is usually a natural change related to a decrease in circulating blood estrogen levels. [3]
Can Medicare help cover the costs of HRT for menopause treatment? Read on to learn more about Medicare coverage and HRT for treating menopause in females older than 65 years.
The female body has estrogen receptors almost everywhere, Garrison explains, so, as estrogen levels begin to fluctuate during perimenopause, then drop after menopause, the impacts can be far-reaching.
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