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History of aspirin. Aspirin (acetylsalicylic acid), an organic compound that does not occur in nature, was first synthesised in 1899. In 1897, scientists at the drug and dye firm Bayer began investigating acetylated organic compounds as possible new medicines, following the success of acetanilide ten years earlier.
Aspirin is also used long-term to help prevent further heart attacks, ischaemic strokes, and blood clots in people at high risk. [10] For pain or fever, effects typically begin within 30 minutes. [10] Aspirin works similarly to other NSAIDs but also suppresses the normal functioning of platelets. [10] One common adverse effect is an upset ...
Aspirin acts as an acetylating agent where an acetyl group is covalently attached to a serine residue in the active site of the COX enzyme. [1] This makes aspirin different from other NSAIDs (such as diclofenac and ibuprofen), which are reversible inhibitors; aspirin creates an allosteric change in the structure of the COX enzyme. [2]
Several studies have found that taking aspirin may lower the risk of developing colon cancer and polyps, per the American Cancer Society (ACS). Aspirin may boost the body’s immune response ...
Bayer Animation. Website. bayerus.com. Bayer Corporation (also known as Bayer USA) is the American subsidiary of Bayer AG. Its main offices are located in Whippany, New Jersey. In addition it has 40 fully consolidated subsidiary companies [3] located in 19 different states. [4]
The Great Phenol Plot was a clandestine effort by the German government during the early years of World War I to divert American-produced phenol from the manufacture of high explosives that supported the British war effort. It was used by the German-owned Bayer company, which could no longer import phenol from Britain, to produce aspirin.
Felix Hoffmann (21 January 1868 – 8 February 1946) was a German chemist notable for re-synthesising diamorphine (independently from C.R. Alder Wright who synthesized it 23 years earlier), which was popularized under the Bayer trade name of "heroin". He is also credited with synthesizing aspirin, though whether he did this under his own ...
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