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In general, small molecules are also easier to crystallize than macromolecules; however, X-ray crystallography has proven possible even for viruses and proteins with hundreds of thousands of atoms, through improved crystallographic imaging and technology. [96] The technique of single-crystal X-ray crystallography has three basic steps.
David Sayre (March 2, 1924 – February 23, 2012) was an American scientist, credited with the early development of direct methods for protein crystallography and of diffraction microscopy (also called coherent diffraction imaging).
2005 - The first X-ray free-electron laser in the soft X-ray regime, FLASH, became an operational user facility at DESY for X-ray diffraction experiments. [ 252 ] 2007 - Ute Kolb and co-workers developed automated diffraction tomography for electron crystallography by combining diffraction and tomography within a transmission electron microscope .
Portrait of William Lawrence Bragg taken when he was around 40 years old. Sir William Lawrence Bragg (31 March 1890 – 1 July 1971), known as Lawrence Bragg, was an Australian-born British physicist and X-ray crystallographer, discoverer (1912) of Bragg's law of X-ray diffraction, which is basic for the determination of crystal structure.
Dorothy Mary Crowfoot Hodgkin OM FRS HonFRSC [9] [10] (née Crowfoot; 12 May 1910 – 29 July 1994) was a Nobel Prize-winning English chemist who advanced the technique of X-ray crystallography to determine the structure of biomolecules, which became essential for structural biology.
This is an accepted version of this page This is the latest accepted revision, reviewed on 12 February 2025. British X-ray crystallographer (1920–1958) This article is about the chemist. For the Mars rover named after her, see Rosalind Franklin (rover). Rosalind Franklin Franklin with a microscope in 1955 Born Rosalind Elsie Franklin (1920-07-25) 25 July 1920 Notting Hill, London, England ...
Pauling's approach combined methods and results from X-ray crystallography, molecular model building, and quantum chemistry. His discoveries inspired the work of Rosalind Franklin , James Watson , Francis Crick , and Maurice Wilkins on the structure of DNA , which in turn made it possible for geneticists to crack the DNA code of all organisms.
Paul Niggli (26 June 1888 – 13 January 1953) was a Swiss crystallographer, mineralogist, and petrologist who was a leader in the field of X-ray crystallography. Education and career [ edit ]