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Depression may be related to abnormalities in the circadian rhythm, [22] or biological clock. A well synchronized circadian rhythm is critical for maintaining optimal health . Adverse changes and alterations in the circadian rhythm have been associated with various neurological disorders and mood disorders including depression.
Depression is a significant mental illness with physiological and psychological consequences, including sluggishness, diminished interest and pleasure, and disturbances in sleep and appetite. [1] It is predicted that by the year 2030, depression will be the number one cause of disability in the United States and other high-income countries. [2]
One reason depression is thought to be a pathology is that it causes so much psychic pain and distress. However, physical pain is also very distressful, yet it has an evolved function: to inform the organism that it is being damaged, to motivate it to withdraw from the source of damage, and to learn to avoid such damage-causing circumstances in the future.
Biological psychiatry or biopsychiatry is an approach to psychiatry that aims to understand mental disorder in terms of the biological function of the nervous system.It is interdisciplinary in its approach and draws on sciences such as neuroscience, psychopharmacology, biochemistry, genetics, epigenetics and physiology to investigate the biological bases of behavior and psychopathology.
From a cognitive perspective, depressive disorders are characterized by people's dysfunctional negative views of themselves, their life experience (and the world in general), and their future—the cognitive triad. People with depression often view themselves as unlovable, helpless, doomed or deficient.
Figure 1: The adaptive and maladaptive cycles resulting from agonistic (hierarchical) encounters. [5]Unlike other evolutionary explanations of depression, rank theory is able to explain why depression is incapacitating: [1] by functioning as a substitute for physical damage, incapacitation prevents the 'loser' from posing a threat to the competitor they challenged.
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