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These medications are also successful for the treatment of restless legs syndrome. In one study, co-careldopa was superior to dextropropoxyphene in decreasing the number of leg kicks and the number of arousals per hour of sleep. However, co-careldopa and, to a lesser extent, pergolide may shift the leg movements from the nighttime to the ...
Medications used may include dopamine agonists and gabapentinoids in those with daily restless legs syndrome. [1] [35] [7] [8] In severe or refractory cases, opioids have been used. [68] Treatment of RLS should not be considered until possible medical causes are ruled out.
Nocturnal leg cramps are involuntary muscle contractions that occur in the calves, soles of the feet, or other muscles in the body during the night or (less commonly) while resting. The duration of nocturnal leg cramps is variable, with cramps lasting anywhere from a few seconds to several minutes.
Of patients that enrolled in a 1, 3, 6, 12 and 24 month study, perceived weakness was reported in 35.3%, 47.1% experienced numbness, 70.6% had tingling, cramps were present in 64.7% and after 24 months, only 5% had their symptoms resolved. Of all the patients, none developed Motor Neuron Disease. [11]
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Eperisone should be administered with care in patients with a history of hypersensitivity to any medication, or with disorders of liver function (it may aggravate hepatic dysfunction). Weakness, light-headedness, sleepiness or other symptoms may occur. In the event of such symptoms, the dosage should be reduced or treatment discontinued.
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