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In histology (microscopic anatomy), the lobules of liver, or hepatic lobules, are small divisions of the liver defined at the microscopic scale. The hepatic lobule is a building block of the liver tissue , consisting of portal triads, hepatocytes arranged in linear cords between a capillary network, and a central vein .
Congenital hepatic fibrosis is an inherited fibrocystic liver disease associated with proliferation of interlobular bile ducts within the portal areas and fibrosis that do not alter hepatic lobular architecture. The fibrosis would affect resistance in portal veins leading to portal hypertension. [citation needed]
The quadrate lobe is an area of the liver situated on the undersurface of the medial segment left lobe (Couinaud segment IVb), bounded in front by the anterior margin of the liver, behind by the porta hepatis, on the right by the fossa for the gall-bladder, and on the left by the fossa for the umbilical vein.
It is formed by the union of the right hepatic duct (which drains bile from the right functional lobe of the liver) and the left hepatic duct (which drains bile from the left functional lobe of the liver). [3] The duct is about 3 cm long. [4] The common hepatic duct is about 6 mm in diameter in adults, with some variation. [5]
1: Right lobe of liver 2: Left lobe of liver 3: Quadrate lobe of liver 4: Round ligament of liver 5: Falciform ligament 6: Caudate lobe of liver 7: Inferior vena cava 8: Common bile duct 9: Hepatic artery 10: Portal vein 11: Cystic duct 12: Hepatic duct 13: Gallbladder
10–11. Right and left lobes of liver 12. Spleen 13. Esophagus 14. Stomach 15. Pancreas: 16. Accessory pancreatic duct 17. Pancreatic duct 18. Small intestine: 19. Duodenum 20. Jejunum 21–22. Right and left kidneys The front border of the liver has been lifted up (brown arrow). [1]
The right vertical limb of the "H" defines the left and right functional lobes, while the left vertical limb of the "H" defines the right and left anatomical lobes. The horizontal line between the vertical limbs of the "H" represents the porta hepatis. The quadrate and caudate lobe lie superior and inferior to this line respectively.
The first symptoms typically include fever, intermittent abdominal pain, and an enlarged liver.Occasionally, yellow discoloration of the skin occurs. [4] Caroli disease usually occurs in the presence of other diseases, such as autosomal recessive polycystic kidney disease, cholangitis, gallstones, biliary abscess, sepsis, liver cirrhosis, kidney failure, and cholangiocarcinoma (7% affected). [2]