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Apixaban is a highly selective, orally bioavailable, and reversible direct inhibitor of free and clot-bound factor Xa. Factor Xa catalyzes the conversion of prothrombin to thrombin, the final enzyme in the coagulation cascade that is responsible for fibrin clot formation. [ 27 ]
The p-methoxy group of apixaban connects to S1 pocket of FXa but does not appear to have any interaction with any residues in this region of FXa. The pyrazole N-2 nitrogen atom of apixaban interacts with Gln-192 and the carbonyl oxygen interacts with Gly-216. The phenyl lactam group of apixaban is positioned between Tyr-99 and Phe-174 and due ...
Absorption is the journey of a drug travelling from the site of administration to the site of action. [1] [2]The drug travels by some route of administration (oral, topical-dermal, etc.) in a chosen dosage form (e.g., tablets, capsules, or in solution). [3]
Nursing Times editor John Gilbert said: ‘The scandal of nurses leaving the profession in pain and with their lives and careers in tatters must end.’ Nursing Times launched Open Learning in 1991, the distance learning package for enrolled nurse conversion. Another high-profile campaign was 1995’s ‘Nursing Times Says Nurses Need 3% Pay Up ...
BMC Nursing is an open access peer-reviewed nursing journal published by BioMed Central covering all aspects of nursing research, training, education, and practice.. Publishers of Nursing journals have traditionally been slow to move to online and open access publishing, meaning BMC Nursing's launch in 2002 has made it one of the most widely known open access journals in the field.
The National Institute of Nursing Research (NINR), as part of the U.S. National Institutes of Health, supports clinical and basic research to establish a scientific basis for the nursing care of individuals across the life span—from management of patients during illness and recovery, to the reduction of risks for disease and disability, and the promotion of healthy lifestyles.
PICOT formatted questions address the patient population (P), issue of interest or intervention (I), comparison group (C), outcome (O), and time frame (T). Asking questions in this format assists in generating a search that produces the most relevant, quality information related to a topic, while also decreasing the amount of time needed to produce these search results.
The American Journal of Nursing (AJN) is a monthly [1] peer-reviewed nursing journal established in 1900. As of 2022 [update] the editor-in-chief is Carl Kirton [ 1 ] and it is published by Lippincott Williams & Wilkins .