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N1-Methyl-2-pyridone-5-carboxamide (also known as 1-methyl-6-oxopyridine-3-carboxamide or nudifloramide and abbreviated as 2PY, 2-Py or NMPC) is one of a number of metabolic products of nicotinamide adenine dinucleotide (NAD) degradation.
With a pK a of 5.25 for its conjugate acid, pyridine is about 15x less basic than imidazole. Pyridine is a weak pi-acceptor ligand. Trends in the M-N distances for complexes of the type [MCl 2 (py) 4] 2+ reveal an anticorrelation with d-electron count. [2]
N 1-Methyl-4-pyridone-3-carboxamide, also abbreviated as 4PY, is a breakdown product of niacin and NAD, [2] that is associated with an increased risk of cardiovascular disease. [3] It has 2 carbonyl groups that are close to each other. [4] [5] [6]
In the basic structure of Pd-PEPPSI, R 1 can be a methyl (CH 3, Me), ethyl (C 2 H 5, Et), isopropyl (C 3 H 7, i Pr), isopentyl (C 5 H 11, i Pent), or isoheptyl (C 7 H 15, i Hept) group, and starting from the second in the row the resulting catalysts are thus labeled as PEPPSI-IEt, PEPPSI-IPr, PEPPSI-IPent, and PEPPSI-IHept respectively, with or without "Pd-" added in front. [7]
N1-Methylpseudouridine is the methylated derivative of pseudouridine. It is used in in vitro transcription and for the production of RNA vaccines. [3] [4] In vertebrates, it stimulates significantly less activation of the innate immune response compared to uridine, [5] while the translation is stronger.
N-Methyl-2-pyrrolidone (NMP) is an organic compound consisting of a 5-membered lactam. It is a colorless liquid, although impure samples can appear yellow. It is miscible with water and with most common organic solvents. It also belongs to the class of dipolar aprotic solvents such as dimethylformamide and dimethyl sulfoxide.
Methylpyridinium is prepared by treating pyridine with dimethylsulfate: [2] C 5 H 5 N + (CH 3 O) 2 SO 2 → [C 5 H 5 NCH 3] + CH 3 OSO − 3. It is found in some coffee products. [3] It is not present in unroasted coffee beans, but is formed during roasting from its precursor chemical, trigonelline. [3]
MMB-2201 (also known as MMB-5F-PICA, [1] 5F-MMB-PICA, 5F-AMB-PICA, and I-AMB) is a potent indole-3-carboxamide based synthetic cannabinoid, [2] which has been sold as a designer drug and as an active ingredient in synthetic cannabis blends. [3]