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N-Hydroxysuccinimide (NHS) is an organic compound with the formula (CH 2 CO) 2 NOH. It is a white solid that is used as a reagent for preparing active esters in peptide synthesis. It can be synthesized by heating succinic anhydride with hydroxylamine or hydroxylamine hydrochloride .
In this usage, a leaving group is a less formal but more commonly used synonym of the term nucleofuge. In this context, leaving groups are generally anions or neutral species, departing from neutral or cationic substrates, respectively, though in rare cases, cations leaving from a dicationic substrate are also known. [3]
Agenda for Change (AfC) is the current National Health Service (NHS) grading and pay system for NHS staff, with the exception of doctors, dentists, apprentices and some senior managers. It covers more than 1 million people and harmonises their pay scales and career progression arrangements across traditionally separate pay groups, in the most ...
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This means that the better the leaving group, the faster the reaction rate. A general rule for what makes a good leaving group is the weaker the conjugate base, the better the leaving group. In this case, halogens are going to be the best leaving groups, while compounds such as amines, hydrogen, and alkanes are going to be quite poor leaving ...
While the cost-of-living crisis is affecting lower-paid staff the most, the pressures are being felt across the board, NHS Providers said. NHS staff ‘leaving for better paid jobs in retail ...
Leaving group reactivity of alcohols can be increased with sulfonates, such as tosylate (− OTs), triflate (− OTf), and mesylate (− OMs). Poor leaving groups include hydroxide (− OH), alkoxides (− OR), and amides (− NR 2). The Finkelstein reaction is one S N 2 reaction in which the leaving group can also act as a nucleophile. In this ...