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Chemotherapy-induced acral erythema, also known as palmar-plantar erythrodysesthesia or hand-foot syndrome is reddening, swelling, numbness and desquamation (skin sloughing or peeling) on palms of the hands and soles of the feet (and, occasionally, on the knees, elbows, and elsewhere) that can occur after chemotherapy in patients with cancer.
Pain and sensory abnormalities can persist for months or years after treatment completion. Some patients may experience “coasting,” where symptoms intensify after completion of treatment. [3] As such, patients can be cancer-free and still suffer from disabling neuropathy induced by cancer treatment. [3]
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Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. [3] [4] Cancer can be difficult to diagnose because its signs and symptoms are often nonspecific, meaning they may be general phenomena that do not point directly to a specific disease process.
When clubbing is observed, pseudoclubbing should be excluded before making the diagnosis. Associated conditions may be identified by taking a detailed medical history —particular attention is paid to lung, heart, and gastrointestinal conditions—and conducting a thorough clinical examination , which may disclose associated features relevant ...
Williams, who also has Graves' disease and lymphedema, was diagnosed in 2023 after she “began to lose words, act erratically at times and have difficulty understanding financial transactions ...
And for dementia, up to 10 years before clinical diagnosis is made. “It really might be possible to develop simple blood tests that can detect disease much earlier than currently exists.
Some cancers can cause a systemic inflammatory state that leads to ongoing muscle loss and weakness, known as cachexia. [34] Some cancers, such as Hodgkin's disease, leukemias, and liver or kidney cancers, can cause a persistent fever. [31] Shortness of breath, called dyspnea, is a common symptom of cancer and its treatment.
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