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This work led to the isolation of sulforaphane, found in broccoli, as a potent inducer of detoxifying phase two enzymes. These findings, published in 1992, [ 4 ] attracted worldwide attention as a major breakthrough in understanding the link between cruciferous vegetable consumption and reduced cancer risk.
Sulforaphane (sometimes sulphoraphane in British English) is a compound within the isothiocyanate group of organosulfur compounds. [1] It is produced when the enzyme myrosinase transforms glucoraphanin, a glucosinolate, into sulforaphane upon damage to the plant (such as from chewing or chopping during food preparation), which allows the two compounds to mix and react.
Although there has been some basic research on how sulforaphane might exert beneficial effects in vivo, there is no high-quality evidence for its efficacy against human diseases. [ 2 ] [ 3 ] Broccoli sprouts also contain a particular glucosinolate compound, glucoraphanin , which is found in vacuoles within the cytoplasm of the plant cell.
The fractional kill hypothesis states that a defined chemotherapy concentration, applied for a defined time period, will kill a constant fraction of the cells in a population, independent of the absolute number of cells. [1] [2] [3] In solid tumors, poor access of the tumor to the drug can limit the fraction of tumor cells killed, but the ...
Apoptosis is a multi-step, multi-pathway cell-death programme that is inherent in every cell of the body. In cancer, the apoptosis cell-division ratio is altered. Cancer treatment by chemotherapy and irradiation kills target cells primarily by inducing apoptosis. [97]
A teen who created a soap that could "transform skin cancer treatment" was chosen as the 2024 Kid of the Year by Time magazine and Time for Kids.. Heman Bekele from Annandale, Virginia, is a 15 ...
Radiation therapy or radiotherapy (RT, RTx, or XRT) is a treatment using ionizing radiation, generally provided as part of cancer therapy to either kill or control the growth of malignant cells. It is normally delivered by a linear particle accelerator .
Glucoraphanin is a glucosinolate found in broccoli, [1] [2] mustard and other cruciferous vegetables. [3] [4] Glucoraphanin is converted to sulforaphane by the enzyme myrosinase. [5] In plants, sulforaphane deters insect predators and acts as a selective antibiotic. [6]