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OT can modify heart rates and cause excessive fluid intake (antidiuretic effect). Intravenous infusion (IV) of oxytocin is often used to induce labor and enhance milk lactation during postpartum care. IV use can cause side-effects such as cardiovascular manifestations in the form of tachycardia and bradycardia. In addition, nausea, vomiting ...
It is registered in many countries for use in suppressing premature labor between 24 and 33 weeks of gestation. It has fewer side effects than drugs previously used for this purpose (such as ritodrine, salbutamol and terbutaline). [11] Oxytocin has not been found to be useful for improving breastfeeding success. [12]
Induced labor may be more painful for the woman as one of the side effects of intravenous oxytocin is increased contraction pains, mainly due to the rigid onset. [34] This may lead to the increased use of analgesics and other pain-relieving pharmaceuticals. [35]
Oxytocin is a peptide hormone and neuropeptide normally produced in the hypothalamus and released by the posterior pituitary. [4] Present in animals since early stages of evolution, in humans it plays roles in behavior that include social bonding, love, reproduction, childbirth, and the period after childbirth.
Oxytocin/ergometrine (trade name Syntometrine) is an obstetric combination drug. The components are synthetically produced oxytocin , a human hormone produced in the hypothalamus , and ergometrine , an alpha-adrenergic , dopaminergic and serotonin (5-HT 2 ) receptor agonist.
Common side effects of carbetocin include vomiting, fever, and hypertension- similar side effect profile to that of oxytocin. [10] Both carbetocin and oxytocin are listed on the World Health Organization's Essential Medicines List. [10] Demoxytocin is another analog of oxytocin which is also used to induce labor.
During pregnancy, the synthesis of oxytocin receptors in the uterus greatly increases, reaching a peak during labor and delivery. Consequently, the administration of carbetocin or another oxytocin analog during or immediately following birth will have increased uterotonic and contractile effect.
Effects last between 45 and 180 minutes. [6] Common side effect include high blood pressure, vomiting, seizures, headache, and low blood pressure. [6] Other serious side effects include ergotism. [6] It was originally made from the rye ergot fungus but can also be made from lysergic acid.