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  2. Integrin alpha X - Wikipedia

    en.wikipedia.org/wiki/Integrin_alpha_X

    CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c . [ 5 ] [ 6 ] CD11c is an integrin alpha X chain protein.

  3. Knockout mouse - Wikipedia

    en.wikipedia.org/wiki/Knockout_mouse

    A knockout mouse (left) that is a model for obesity, compared with a normal mouse. There are several thousand different strains of knockout mice. [3] Many mouse models are named after the gene that has been inactivated.

  4. International Knockout Mouse Consortium - Wikipedia

    en.wikipedia.org/wiki/International_Knockout...

    [2] [3] Many of the targeted alleles are designed so that they can generate both complete and conditional gene knockout mice. [3] [4] The IKMC was initiated on March 15, 2007, at a meeting in Brussels. By 2011, Nature reported that approximately 17,000 different genes have already been disabled by the consortium, "leaving only around 3,000 more ...

  5. Gene knock-in - Wikipedia

    en.wikipedia.org/wiki/Gene_Knock-in

    Gene knock-in originated as a slight modification of the original knockout technique developed by Martin Evans, Oliver Smithies, and Mario Capecchi.Traditionally, knock-in techniques have relied on homologous recombination to drive targeted gene replacement, although other methods using a transposon-mediated system to insert the target gene have been developed. [3]

  6. International Mouse Phenotyping Consortium - Wikipedia

    en.wikipedia.org/wiki/International_Mouse_Pheno...

    The International Mouse Phenotyping Consortium (IMPC) is an international scientific endeavour to create and characterize the phenotype of 20,000 knockout mouse strains. [1] [2] [3] Launched in September 2011, [1] the consortium consists of over 15 research institutes across four continents with funding provided by the NIH, European national governments and the partner institutions.

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  8. Genetically modified mouse - Wikipedia

    en.wikipedia.org/wiki/Genetically_modified_mouse

    The genetically modified mouse in which a gene affecting hair growth has been knocked out (left) shown next to a normal lab mouse. A genetically modified mouse, genetically engineered mouse model (GEMM) [1] or transgenic mouse is a mouse (Mus musculus) that has had its genome altered through the use of genetic engineering techniques.

  9. Lexicon Pharmaceuticals - Wikipedia

    en.wikipedia.org/wiki/Lexicon_Pharmaceuticals

    Lexicon Pharmaceuticals, Inc. is a biopharmaceutical company developing treatments for human disease. The company was founded in 1995 in The Woodlands, Texas under the name Lexicon Genetics, Incorporated by co-founders Professor Allan Bradley, FRS and Professor Bradley's postdoctoral fellow Arthur T Sands. [2]

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