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The first significantly controversial card grade was in fact the first card ever graded by PSA. This was the T206 Honus Wagner card. Originally it achieved a NM-MT 8 grade. This card was originally owned by Sotheby's Sport's Consultant Bill Mastro, and purchased by Wayne Gretzky and Bruce McNall. [3]
A more refined prognosis can be established by consideration of prostate-specific antigen, and grade (i.e. Gleason score in the Gleason grading system). For example, it is common to classify patients into high, intermediate and low-risk groups on the basis of these three factors (TNM stage, PSA and Gleason score).
For example, if the primary tumor grade was 2 and the secondary tumor grade was 3 but some cells were found to be grade 4, the Gleason score would be 2+4=6. This is a slight change from the pre-2005 Gleason system where the second number was the secondary grade (i.e., the grade of the second-most common cell line pattern).
Grade Groups range from 1, or likely to grow and spread slowly, to 5, or likely to grow and spread quickly, according to the ACS: Grade Group 1 = Gleason 6 (or less) Grade Group 2 = Gleason 3+4=7
Those with localized tumors and PSA between 10 and 20 ng/mL are designated stage II – subdivided into IIA for Gleason grade group 1, IIB for grade group 2, and IIC for grade group 3 or 4. Stage III is the designation for any of three higher risk factors: IIIA is for a PSA level about 20 ng/mL; IIIB is for T3 or T4 tumors; IIIC is for a ...
Cards are evaluated by third-party services, most often Professional Sports Authenticator (PSA), Beckett Grading Services (BGS) and Sportscard Guaranty (SGC), and given a grade on a ten-point scale based on condition. [5] The images below do not necessarily represent the individual specimen sold but are representative of the given cards.
Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), P-30 antigen, is a glycoprotein enzyme encoded in humans by the KLK3 gene.PSA is a member of the kallikrein-related peptidase family and is secreted by the epithelial cells of the prostate gland in men and the paraurethral glands in women.
The Professional Sports Authenticator (PSA) company graded this card a PSA 8 Near Mint-Mint (NM-MT) on their 10-point scale, [31] [32] the highest grade given to a T206 Honus Wagner card. Bill Hughes [33] was the official grader of the card, working for PSA at the time. Hughes admitted to knowing that the card had been altered when he graded it.
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