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Selamectin, sold under the brand name Revolution, among others, is a topical parasiticide and anthelminthic used on dogs and cats. [2] It treats and prevents infections of heartworms , fleas , ear mites , sarcoptic mange (scabies), and certain types of ticks in dogs, and prevents heartworms, fleas, ear mites, hookworms , and roundworms in cats.
Pharmacokinetic interaction of the antiparasitic agents ivermectin and spinosad in dogs. Drug Metab Dispos. 2011 May;39(5):789-95. doi: 10.1124/dmd.110.034827. Epub 2011 Feb 14.
Ivermectin has not yet been proven to replace chemotherapy in dogs with melanoma. In humans, however, ivermectin has been found to be effective when used with a melanoma chemotherapy drug called ...
In mice, ivermectin was tested in vivo with doxorubicin, and treatment rates were better than with chemotherapy alone (3). The dose of ivermectin used did not have toxic effects in mice.
A topical preparation of 0.01% ivermectin can be used directly as an oil in cat ears, and the related new generation drug selamectin (brand name "Revolution") is available as a once-per-month skin treatment for both dogs and cats, which will prevent new mite infestation as well as a number of other parasitic diseases.
Mange (/ ˈ m eɪ n dʒ /) is a type of skin disease caused by parasitic mites. [1] Because various species of mites also infect plants, birds and reptiles, the term "mange", or colloquially "the mange", suggesting poor condition of the skin and fur due to the infection, is sometimes reserved for pathological mite-infestation of nonhuman mammals.
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