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Tylenol PM contains diphenhydramine in addition to acetaminophen for the purpose of inducing sleep and reducing pain and/or fever. [12] Promethazine is marketed by the brand name Phenergan for use against allergy symptoms and motion sickness in the US, where a prescription for promethazine is required. [13]
Over time, often 3–6 years, drugs that prove themselves safe and appropriate as prescription medicines may be switched from prescription to OTC. [citation needed] An example of this is diphenhydramine (Benadryl), an anti-histamine which once required a prescription but now is available OTC nearly everywhere.
Diphenhydramine, sold under the brand name Benadryl among others, is an antihistamine and sedative. It is a first-generation H 1 -antihistamine and it works by blocking certain effects of histamine , which produces its antihistamine and sedative effects.
In 2020, purposeful overmedication with Benadryl (diphenhydramine) was a concern due to use of social media by teenagers in the United States, with the FDA issuing a public warning about the possibility of seizures, hallucinations, breathing difficulty or loss of consciousness.
Contains 250 mg acetaminophen, 250 mg aspirin and 65 mg caffeine. 1969: Excedrin PM – Excedrin PM is the first headache and sleeping pill combination product. [8] Contains 500 mg acetaminophen and 38 mg diphenhydramine citrate as a sleep aid. Those same active ingredients were later utilized several years later in the product Tylenol PM.
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