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where H is HDL cholesterol, L is LDL cholesterol, C is total cholesterol, T are triglycerides, and k is 0.20 if the quantities are measured in mg/dL and 0.45 if in mmol/L. There are limitations to this method, most notably that samples must be obtained after a 12 to 14 h fast and that LDL-C cannot be calculated if plasma triglyceride is >4.52 ...
The Friedewald method is reasonably reliable for the majority of patients, but is notably inaccurate in patients with hypertriglyceridemia (> 400 mg/dL or 4.5 mmol/L). It also underestimates LDL-C in patients with low LDL-C (< 25 mg/dL or 0.6 mmol/L). It does not take into account intermediate-density lipoprotein. [1]
Cholesterol is tested to determine for "normal" or "desirable" levels if a person has a total cholesterol of 5.2 mmol/L or less (200 mg/dL), an HDL value of more than 1 mmol/L (40 mg/dL, "the higher, the better"), an LDL value of less than 2.6 mmol/L (100 mg/dL), and a triglycerides level of less than 1.7 mmol/L (150 mg/dL).
For example, lowering your LDL cholesterol by 1 millimole per liter (mmol/L) can reduce your risk of major vascular events by about 20 percent — regardless of your initial LDL level.
LDL total cholesterol – HDL – (0.2 x fasting triglycerides). [43] However, this equation is not valid on nonfasting blood samples or if fasting triglycerides are elevated (>4.5 mmol/L or >~400 mg/dL). Recent guidelines have, therefore, advocated the use of direct methods for measurement of LDL wherever possible. [39]
mg/dL Full blood glucose (fasting) 3.3 [5] 5.6 [5] mmol/L 60 [177] 100 [177] mg/dL Random glucose: 3.9 [178] 7.8 [178] mmol/L 70 [179] 140 [179] mg/dL Lactate (Venous) 4.5 [23] 19.8 [23] mg/dL: 0.5 [180] 2.2 [180] mmol/L: Lactate (Arterial) 4.5 [23] 14.4 [23] mg/dL: 0.5 [180] 1.6 [180] mmol/L: Pyruvate: 300 [23] 900 [23] μg/dL: 34 [181] 102 ...
According to the American Heart Association in 1994, only total cholesterol levels below 160 mg/dL or 4.1 mmol/L are to be classified as "hypocholesterolemia". [2] However, this is not agreed on universally and some put the level lower. [citation needed]
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