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Ezetimibe, sold under the brand name Zetia among others, is a medication used to treat high blood cholesterol and certain other lipid abnormalities. [3] [4] Generally it is used together with dietary changes and a statin. [5] Alone, it is less preferred than a statin. [4] It is taken by mouth. [4]
It is a combination of ezetimibe (known as Zetia in the United States) and the statin drug simvastatin (known as Zocor in the US). Ezetimibe reduces blood cholesterol by acting at the brush border of the small intestine and inhibiting the absorption of cholesterol, leading to a decrease in the delivery of intestinal cholesterol to the liver.
“Despite statins reducing risks of heart attacks and strokes, historically in the U.S., women have also received less aggressive treatment than men in terms of cholesterol management,” Mehta said.
Ezetimibe/atorvastatin (trade names Liptruzet, Atozet) is a cholesterol lowering combination drug.In the United States, it was approved in May 2013, by the Food and Drug Administration for the treatment of elevated low-density lipoprotein (LDL) in patients with primary or mixed hyperlipidemia as adjunctive therapy to diet. [1]
More than one third of women believe that doctors are too aggressive when it comes to statin medication, versus 28% of men, and 20% would discontinue statin treatment without consulting their ...
Zetia received FDA approval in 2002 and became the first significant competition for the statin class that held the cholesterol market for more than two decades. Statins such as Pfizer's best ...
The first study involved 382 participants also taking the maximum tolerated doses of statins. [2] After three months, LDL cholesterol levels were reduced by 36% in participants taking bempedoic acid and ezetimibe compared with a reduction of 23% with ezetimibe alone, 17% with bempedoic acid alone and an increase of around 2% with placebo (a ...
Statins and non-statins may also be used together in some cases. “Sometimes a statin is not controlling cholesterol, so we add the non-statin medication as an adjunct,” said Harb.