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The lateral corticospinal tract is a descending motor pathway that begins in the cerebral cortex, decussates in the pyramids of the lower medulla [1] (also known as the medulla oblongata or the cervicomedullary junction, which is the most posterior division of the brain [2]) and proceeds down the contralateral side of the spinal cord.
A frequently occurring motor deficit is left-sided hemiparesis (in strokes affecting the motor cortex). A less common motor deficit in this population is dysphagia. [4] Patients with right hemisphere brain damage often display sensory deficits such as left neglect, in which they ignore everything in the left visual field. [5]
Frontal lobe disorder, also frontal lobe syndrome, is an impairment of the frontal lobe of the brain due to disease or frontal lobe injury. [5] The frontal lobe plays a key role in executive functions such as motivation, planning, social behaviour, and speech production.
Subacute combined degeneration of spinal cord, also known as myelosis funiculus, or funicular myelosis, [1] also Lichtheim's disease, [2] [3] and Putnam-Dana syndrome, [4] refers to degeneration of the posterior and lateral columns of the spinal cord as a result of vitamin B 12 deficiency (most common).
UMNs are motor neurons that project from the cortex down to the brainstem or spinal cord. [18] LMNs originate in the anterior horns of the spinal cord and synapse on peripheral muscles. [18] Both motor neurons are necessary for the strong contraction of a muscle, but damage to an UMN can be distinguished from damage to a LMN by physical exam. [19]
Cortical stimulation mapping led to the development of a homunculus for the motor and sensory cortices, which is a diagram showing the brain's connections to different areas of the body. An example is the cortical homunculus of the primary motor cortex and the somatosensory cortex, which are separated by the central sulcus.
The dorsal column–medial lemniscus pathway (DCML) (also known as the posterior column-medial lemniscus pathway (PCML) is the major sensory pathway of the central nervous system that conveys sensations of fine touch, vibration, two-point discrimination, and proprioception (body position) from the skin and joints.
No cure for Parkinson's is known, and treatment focuses on alleviating symptoms. Initial treatment typically includes L-DOPA, MAO-B inhibitors, or dopamine agonists. As the disease progresses, these medications become less effective and may cause involuntary muscle movements. Diet and rehabilitation therapies can help improve symptoms.
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