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Thiazolidinedione ligand dependent transactivation is responsible for the majority of anti-diabetic effects. The activated PPAR/RXR heterodimer binds to peroxisome proliferator hormone response elements upstream of target genes in complex with a number of coactivators such as nuclear receptor coactivator 1 and CREB binding protein, this causes upregulation of genes (for a full list see PPARγ):
Thiazolidine is a heterocyclic organic compound with the formula (CH2)3(NH)S. It is a 5-membered saturated ring with a thioether group and an amine group in the 1 and 3 positions. It is a sulfur analog of oxazolidine .
It is classified as a heterocycle called a thiazolidine. It is a colorless or off-white solid. It has gained attention as a proposed low toxicity replacement for ethylenethioureas, which are used as accelerators for the vulcanization of chloroprene rubbers. [1] The compound is prepared by reaction of N-methylethanolamine and carbon disulfide.
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Thioproline is a nonproteinogenic amino acid with the formula (CH 2 SCH 2 NHCH)CO 2 H, although it crystallizes as the zwitterion (CH 2 SCH 2 NH + 2 CH)CO − 2.It consists of a 1,3-thiazolidine ring ( (CH 2 SCH 2 NHCH 2)) substituted with a carboxylic acid.
Darglitazone (previously known as CP 86325-2) is a member of the thiazolidinedione class of drugs and an agonist of peroxisome proliferator-activated receptor-γ (PPAR-γ), an orphan member of the nuclear receptor superfamily of transcription factors.
Thiazolines (/ θ aɪ ˈ æ z oʊ l iː n z /; or dihydrothiazoles) are a group of isomeric 5-membered heterocyclic compounds containing both sulfur and nitrogen in the ring. Although unsubstituted thiazolines are rarely encountered themselves, their derivatives are more common and some are bioactive.
A diode is a two-terminal electronic component that conducts current primarily in one direction (asymmetric conductance). It has low (ideally zero) ...