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N-acetylphosphatidylethanolamine-hydrolysing phospholipase D (EC 3.1.4.54, NAPE-PLD, anandamide-generating phospholipase D, N-acyl phosphatidylethanolamine phospholipase D, NAPE-hydrolyzing phospholipase D) is an enzyme with systematic name N-acetylphosphatidylethanolamine phosphatidohydrolase. [1] [2] It catalyses the following chemical reaction
A hydrophobic cavity in NAPE-PLD provides an entryway for the substrate NAPE into the active site, where a binuclear zinc center orchestrates its hydrolysis. Unexpectedly, the structure unveils bile acids bind the membrane enzyme, enhancing dimer assembly and enabling catalysis.
N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) is an enzyme that catalyzes the release of N-acylethanolamine (NAE) from N-acyl-phosphatidylethanolamine (NAPE). This is a major part of the process that converts ordinary lipids into chemical signals like anandamide and oleoylethanolamine .
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President-elect Donald Trump had not been terribly successful in suing media organizations until this weekend when ABC News agreed to settle a closely-watched defamation case he brought against ...
Philadelphia teacher Ellen Greenberg's death was ruled a suicide after the 27-year-old was found with 20 stab wounds; her fiancé makes his first public statement on her death.
eBay office in Toronto, Canada. eBay Inc. (/ ˈ iː b eɪ / EE-bay, often stylized as ebay or Ebay) is an American multinational e-commerce company based in San Jose, California, that allows users to buy or view items via retail sales through online marketplaces and websites in 190 markets worldwide.
D cell batteries, wooden matchstick for scale. A D battery (D cell or IEC R20) is a standardized size of a dry cell. A D cell is cylindrical with an electrical contact at each end; the positive end has a nub or bump. D cells are typically used in high current drain applications, such as in large flashlights, radio receivers, and transmitters ...